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● Most important are the gastro-intestinal side-effects of aspirin, which unattended may result in ulcers, gastro-intestinal bleeding, and sometimes even in death.
● Statins can evoke myalgia and, very infrequently, rhabdomyolysis, in extreme cases leading to renal failure.
● Angiotensin converting enzyme inhibitors may trigger persistent cough (switch to angiotensin receptor blockers) and arrhythmia due to potassium accumulation.
● Beta blockers may evoke bradycardic arrhythmia, worsen symptoms of a peripheral artery disease or of asthma. Asthma symptoms may be also evoked by aspirin.
● Glyceryl trinitrate can induce headache and hypotensive episodes.