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How do I calculate the insulin dose for a 70 kg patient with type 1 diabetes?
● To best mimic the physiological insulin excretion, the hormone is usually given as a basal, long-acting insulin, combined with several meal-matched (prandial) injections of a normal insulin.
● The average dose of basal insulin is 0.35 IU/kg/d, corresponding to some 24 IU for a 70 kg individual per day. The cost-effective basal NPH insulin would be typically given as 2 injections of 14 IU in the morning and 10 IU in the evening.
● The typical energy intake of 1800 kcal/d subdivided into 3 equal meals of 600 kcal would require 12 IU of normal insulin in the morning, 6 IU at lunch time, and 9 IU in the evening. These differences reflect the varying efficacy of insulin depending on the time of the day.
● Prandial injections are also used to correct any hyperglycemia, which should be verified by glucose measurement prior to every meal. On average, 1 IU is needed to reduce glycemia by 30 mg/dL.
≣ Slide 32
● The average dose of basal insulin is 0.35 IU/kg/d, corresponding to some 24 IU for a 70 kg individual per day. The cost-effective basal NPH insulin would be typically given as 2 injections of 14 IU in the morning and 10 IU in the evening.
● The typical energy intake of 1800 kcal/d subdivided into 3 equal meals of 600 kcal would require 12 IU of normal insulin in the morning, 6 IU at lunch time, and 9 IU in the evening. These differences reflect the varying efficacy of insulin depending on the time of the day.
● Prandial injections are also used to correct any hyperglycemia, which should be verified by glucose measurement prior to every meal. On average, 1 IU is needed to reduce glycemia by 30 mg/dL.
≣ Slide 32
Karteninfo:
Autor: LWojnowski
Oberthema: Medicine
Thema: Pharmacology
Schule / Uni: University Clinical Center
Ort: Mainz
Veröffentlicht: 24.05.2013