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Metabolism in the liver is mediated through two pathways. Which is most affected in the elderly? Name 3 drugs metabolised by this pathway which should therefore be used with caution in the elderly.
- phase 1 is most affected
- microsomal mixed function oxidase
- metabolising capacity decreases by up to 60%
Drugs metabolised by phase 1 are:
- diazepam, warfarin, phenytoin, analgesics, theophylline.
- microsomal mixed function oxidase
- metabolising capacity decreases by up to 60%
Drugs metabolised by phase 1 are:
- diazepam, warfarin, phenytoin, analgesics, theophylline.
