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What is the effect of aging on renal function? What implications does this have on the prescription of elderly?
Glomeruler Filtration rate (GFR) decreases from the age of 20, by 75 it has decreased by 50%.
N.B creatinine is not a good indicator, because of reduced muscle mass.
The effect on drug choice in the elderly:
- avoid drugs which are nephrotoxic or unsafe in renal impairment
- reduce dose of other renally excreted drugs
N.B creatinine is not a good indicator, because of reduced muscle mass.
The effect on drug choice in the elderly:
- avoid drugs which are nephrotoxic or unsafe in renal impairment
- reduce dose of other renally excreted drugs
