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5
Explain why two sensations (e.g. first and second) can be elicited by activation of nociceptors? How do these sensations differ?
•Pain is sensed in two phases, the first very fast one is conducted via A-fibers and the second slower one by C-fibers.
•Pain transmitted by C-fibers is unlocalized due to peptidergic transmitters (e.g. Substance P which enhances and prolong action of glutamate).
•Pain transmitted by C-fibers is unlocalized due to peptidergic transmitters (e.g. Substance P which enhances and prolong action of glutamate).
