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What is 11
HSD-1 and 11HSD-2?
HSD-1 and 11HSD-2?11HSD-1 converts CORTISONE to CORTISOL, which can be used on a glucocorticoid receptor.
11HSD-2 converts CORTISOL to CORTISONE, which doesn't interact with mineralcorticoid receptors (ie in the kidney)
11HSD2 is found in kidneys and other tissues with mineralcorticoid activity
HSD-1 converts CORTISONE to CORTISOL, which can be used on a glucocorticoid receptor. 11
HSD-2 converts CORTISOL to CORTISONE, which doesn't interact with mineralcorticoid receptors (ie in the kidney)11
HSD2 is found in kidneys and other tissues with mineralcorticoid activity