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What is 11
HSD-1 and 11HSD-2?
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11
HSD-1 converts CORTISONE to CORTISOL, which can be used on a glucocorticoid receptor.
11
HSD-2 converts CORTISOL to CORTISONE, which doesn't interact with mineralcorticoid receptors (ie in the kidney)
11
HSD2 is found in kidneys and other tissues with mineralcorticoid activity
![](/pool/data/tex/b0603860fcffe94e5b8eec59ed813421.gif)
11
![](/pool/data/tex/b0603860fcffe94e5b8eec59ed813421.gif)
11
![](/pool/data/tex/b0603860fcffe94e5b8eec59ed813421.gif)