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18
MS
How common? What is the target & what kind of immune response causes it?
What are the main effector cells, and their effector molecules?
What are the 2 categories of MS?
How common? What is the target & what kind of immune response causes it?
What are the main effector cells, and their effector molecules?
What are the 2 categories of MS?
Main cause of neurological disability in young people
20-30 yo onset
Inflammation of CNS White Matter (myelinated)
Involves T-cell and macrophage => Axonal injury
CD4+ T cells secrete proinflammatory cytokines (TNF-
and IFN-
)
Relapse-remitting (RR) - cycle between acute attack and recover. Can accumulate damage
Progressive (PP) - getting worse
20-30 yo onset
Inflammation of CNS White Matter (myelinated)
Involves T-cell and macrophage => Axonal injury
CD4+ T cells secrete proinflammatory cytokines (TNF-
and IFN-)Relapse-remitting (RR) - cycle between acute attack and recover. Can accumulate damage
Progressive (PP) - getting worse
