List the insulin preps and their onset/duration
Crystalline insulin - rapid onset, short duration
Split mix - mix of crystalline and intermediate
Intermediate Insulin
Split mix - mix of crystalline and intermediate
Intermediate Insulin
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List the Oral Anti-Hyperglycemics
TZDs/PPAR-gamma agonists
biguanides
alpha-glucosidase inhibitors
biguanides
alpha-glucosidase inhibitors
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Mechanism of TZDs
PPAR-gamma agonists, causing increased membrane GLUT4, decreased inflammatory proteins
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Mechanism of PPAR-gamma agonists
increase membrane GLUT4
decrease inflammatory proteins
decrease inflammatory proteins
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Side effects of PPAR-gamma agonists
takes 6-12 weeks to be effective
HEPATOTOXIC
CAUSES MI
HEPATOTOXIC
CAUSES MI
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Side effects of Biguanides
weight loss
improvement of lipid profile
LACTIC ACID ACIDOSIS
RENAL FAILURE WITH IODINATED CONTRAST
improvement of lipid profile
LACTIC ACID ACIDOSIS
RENAL FAILURE WITH IODINATED CONTRAST
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Mechanism of alpha-glucosidase inhibitors
stops intestinal absorption of carbohydrates
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The only drug that can be used for insulin-dependent or insulin-independent diabetes
pralimitide: amylin analog
Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes, type 2 diabetes
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Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes, type 2 diabetes
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Tags: diabetes, drugs, endo, pharmacology, Type I diabetes
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List the Oral Hypoglycemics and their mechanisms
Sulfonylureas - inhibit ATP/K+ channels
Meglitinides - inhibit ATP/K+ channels
Incretin Mimetics (exenatide) - GLP1 agonists
Gliptins - inhibit DPP4 and block GLP1 and GIP metabolism
Meglitinides - inhibit ATP/K+ channels
Incretin Mimetics (exenatide) - GLP1 agonists
Gliptins - inhibit DPP4 and block GLP1 and GIP metabolism
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Tell me everything about first generation Sulfonylureas (names, mechanism, side effects)
tolbutamide, tolazamide, acetohexamide, chlorpropamide
inhibit ATP/K+ channels
SEVERE PROTRACTED HYPOGLYCEMIA THAT KILLS
WEIGHT GAIN
inhibit ATP/K+ channels
SEVERE PROTRACTED HYPOGLYCEMIA THAT KILLS
WEIGHT GAIN
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List the first generation Sulfonylureas
tolbutamide
tolazamide
acetohexamide
chlorpropamide
tolazamide
acetohexamide
chlorpropamide
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Mechanism of second generation Sulfonylureas
inhibit ATP/K+ channels AND increase insulin receptors on tissues
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Side effects of sulfonylureas
First generation: SEVERE PROTRACTED HYPOGLYCEMIA THAT KILLS, weight gain
Second generation: weight gain only
Second generation: weight gain only
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Kartensatzinfo:
Autor: larsonsc
Oberthema: Pharmacology
Thema: DM drugs
Schule / Uni: MSUCOM
Veröffentlicht: 10.03.2010
Schlagwörter Karten:
Alle Karten (56)
classes (1)
diabetes (56)
drug classes (19)
drugs (36)
endo (56)
mechanisms (11)
pharmacology (56)
type 1 diabetes (8)
type 2 diabetes (47)
Type I diabetes (3)