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multiple myelomas- (decreased normal plasma cells) decreased antibodiesholes in bones lead to calcium release) and . elevated monoclonal Ig's in serum/urine. must have 1 major and 1 minor indicator or 3 minor indicators
waldenstrom's macroglobulinemia (IgM class malignancy) causes fatigue mucous membrane bleeding and enlarged lymph nodes and spleen-increased protein/viscosity, normochromic/normocytic anemia, rouleaux blood smear, hypercellular bone marrow, lots of IgM (plasmaphoresis and chemo)

clone of differentiated B cells creates Ig with either light chain only or heavy chain only