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1. Basicity of Nu
       RO- > HO- > RCO > ROH > HO
2. Polarizability (size) of Nu
       CN- > I- > RO- > HO- > Br-
3. Solvent
      -protic = solvate the leaving group.
      -polar = solvate the intermediate.
4. Leaving group (base weakness)
5. Substrate (charge delocalization)