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36
Neurons in the CNS do not regenerate whereas neurons in the PNS may regenerate. What is thought to be the cause for this difference?
•Neurons in the CNS are in principle able to regenerate but this ability is suppressed by central myelin (this may be why myelination occurs late in development).
•The suppression can be abolished by antibodies against NI-35 (“nogo”) which seems to be the main factor.
•In the PNS myelin is not generated by oligodendrocytes but by Schwann cells.
•The suppression can be abolished by antibodies against NI-35 (“nogo”) which seems to be the main factor.
•In the PNS myelin is not generated by oligodendrocytes but by Schwann cells.
