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● Patients should be sensitized to side-effects of the applied drugs which require therapy adjustment, such as cough, hypotensive episodes, dyspnea, arrhythmias, edema, and weight gain.
● On the other hand, you should make clear that the worsening of the kidney function in response to angiotensin converting enzyme inhibitors and to angiotensin and mineralocorticoid receptor blockers as well as cardiac decompensation in response to beta blockers are usually transient. Explaining this will improve the therapy adherence and thereby achieve the intended clinical benefits resulting from reduced cardiac remodelling and improved contractility after several months.