Coccidioidomycosis Immitis & C. posadasii
Valley Fever.
Endemic in south-west USA, Mexico, Central / South America
Can be aerosolized. Infection through respiration.
Dimorphic because they form spheres or Hyphae (the form in the lungs)
Hyphae: IN VITRO. Mold and can be aerosolized
Sphere: IN VIVO. Sphere divides in tissue lesions
Can develop resistance after the first infection. (Hence can have vaccines).
Endemic in south-west USA, Mexico, Central / South America
Can be aerosolized. Infection through respiration.
Dimorphic because they form spheres or Hyphae (the form in the lungs)
Hyphae: IN VITRO. Mold and can be aerosolized
Sphere: IN VIVO. Sphere divides in tissue lesions
Can develop resistance after the first infection. (Hence can have vaccines).
Coccidioidomycosis Immitis & C. posadasii
Range of symptoms
Range of symptoms
60% subclinical. Symptomatic in 40%
Fever, Pneumonia, Rash. Most recover from this severity
ex. rash = Coccidioidal Erythema Nodosum
Dissemination of fungus -> skin, bones, meninges (Polygranulomatous lesions). Possibly lethal if it progresses to this stage
Bad for certain ethnic groups, late pregnancy, immunocompromised pts.
Fever, Pneumonia, Rash. Most recover from this severity
ex. rash = Coccidioidal Erythema Nodosum
Dissemination of fungus -> skin, bones, meninges (Polygranulomatous lesions). Possibly lethal if it progresses to this stage
Bad for certain ethnic groups, late pregnancy, immunocompromised pts.
Symptoms / Diseases of Aspergillus Fumigatus
Makes conidia which are inhaled
Toxicosis - aflatoxin
Allergic Bronchopulmonary disease
-Asthma-like (IgE)
-Farmers lung like (IgE, IgG)
Pneumonitis
Sinusitis
Fungus Ball - pulm cavity
Vasoinvasive disease in immunocompromised form (if Hyphal form)
-Nose / paranasal sinus
Lungs, skin - in neutropenic patients
Risk factors:
Diseases: lymphoma, diabetes mellitus, CF
- Neutropenic pts. (Aplastic Anemia)
- Immunocompromised pts. (organ transplant recipients)
Toxicosis - aflatoxin
Allergic Bronchopulmonary disease
-Asthma-like (IgE)
-Farmers lung like (IgE, IgG)
Pneumonitis
Sinusitis
Fungus Ball - pulm cavity
Vasoinvasive disease in immunocompromised form (if Hyphal form)
-Nose / paranasal sinus
Lungs, skin - in neutropenic patients
Risk factors:
Diseases: lymphoma, diabetes mellitus, CF
- Neutropenic pts. (Aplastic Anemia)
- Immunocompromised pts. (organ transplant recipients)
Flashcard set info:
Author: yaoyu
Main topic: Biology
Topic: Microbiology
Published: 10.02.2010
Tags: Respiratory Fungi
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