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Inflammation resulting form tissue damage causes chemicals to be released and the influx of inflammatory cells. The result is an inflammatory soup of mediators including those that involve
activating
sensitising
recruiting (in the case of silent nociceptors)
nociceptors
This is via interactions on ion channels, receptor specific channels and by second messenger effects. What does that result in?
activating
sensitising
recruiting (in the case of silent nociceptors)
nociceptors
This is via interactions on ion channels, receptor specific channels and by second messenger effects. What does that result in?
-enhanced nociceptor excitability
-an altered response to a given stimulus
-Hyperalgesia - an increased response to a normally painful stimulus
-Nociceptors having an increased receptive field
This barrage of afferent information results in changes in the spinal cord
enhanced spinal nociceptor excitability - secondary hyperalgesia
-an altered response to a given stimulus
-Hyperalgesia - an increased response to a normally painful stimulus
-Nociceptors having an increased receptive field
This barrage of afferent information results in changes in the spinal cord
enhanced spinal nociceptor excitability - secondary hyperalgesia
