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213
explain the Control of feeding by lateral hypothalamic peptides.
-One group of LHA neurones contain melanin-concentrating hormone (MCH)
-MCH receive input from leptin sensitive cells (αMSH/CART) of ACH
-MCH containing neurones connections throughout brain
-monosynaptic innervation mostly to cortex
-Cortex organise/initiates goal-directed behaviours (raiding fridge/drinking more beer)
-MCH cells inform cortex levels leptin, may contribute significantly to motivating the search for food
- alsok LHA neurones contain peptide OREXIN that project to cortex
-Orexin neurones receive direct innervation from ARH
-Orexin stimulating feeding behaviour
-Stimulate MCH & Orexin neurones when leptin levels fall in blood
Inhibit MCH & Orexin neurones when leptin levels increase in blood
Orexin role control sleep links to narcolepsy.
-MCH receive input from leptin sensitive cells (αMSH/CART) of ACH
-MCH containing neurones connections throughout brain
-monosynaptic innervation mostly to cortex
-Cortex organise/initiates goal-directed behaviours (raiding fridge/drinking more beer)
-MCH cells inform cortex levels leptin, may contribute significantly to motivating the search for food
- alsok LHA neurones contain peptide OREXIN that project to cortex
-Orexin neurones receive direct innervation from ARH
-Orexin stimulating feeding behaviour
-Stimulate MCH & Orexin neurones when leptin levels fall in blood
Inhibit MCH & Orexin neurones when leptin levels increase in blood
Orexin role control sleep links to narcolepsy.
