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5T4 ADC, or 5T4 Antibody-Drug Conjugate, represents an emerging and targeted approach in cancer therapy, leveraging the specificity of antibody-based targeting combined with the potent cytotoxic effects of chemotherapy. The 5T4 antigen is a cell surface glycoprotein that is highly expressed on various tumor cells, including those of colorectal, ovarian, gastric, and non-small cell lung cancers, while being minimally present on normal adult tissues. This distinct expression pattern makes 5T4 an attractive target for antibody-drug conjugate development.