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Diabetes (56 Cards)

List the insulin preps and their onset/duration

Crystalline insulin - rapid onset, short duration

Split mix - mix of crystalline and intermediate

Intermediate Insulin

Tags: diabetes, drug classes, endo, pharmacology, Type I diabetes
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List the meglitinides

repaglinide

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Mechanism of action of meglitinides

inhibit the ATP/K+ channel

Tags: classes, diabetes, endo, mechanisms, pharmacology, type 2 diabetes
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List the incretin mimetics

exenatide

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Mechanism of action of incretin mimetics

GLP1 agonist

Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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Side effects of incretin mimetics

TERATOGEN

also, it's from Gila Monster saliva.

Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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7
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List the Gliptins

sitagliptin
vildagliptin

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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List the DPP4 inhibitors

sitagliptin
vildagliptin

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Mechanism of action of the Gliptins

inhibit DPP4, blocking GLP-1 and GIP metabolism

Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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Mechanism of action of DPP4 inhibitors

block the metabolism of GLP-1 and GIP

Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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Functions of oral hypoglycemics

increase insulin
decrease glucagon
induce hypoglycemia

Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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List the Oral Anti-Hyperglycemics

TZDs/PPAR-gamma agonists
biguanides
alpha-glucosidase inhibitors

Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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List the TZDs

rosiglitazone
pioglitazone

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Mechanism of TZDs

PPAR-gamma agonists, causing increased membrane GLUT4, decreased inflammatory proteins

Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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List the PPAR-gamma agonists

rosiglitazone
pioglitazone

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Mechanism of PPAR-gamma agonists

increase membrane GLUT4
decrease inflammatory proteins

Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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Side effects of TZDs

takes 6-12 weeks to be effective

HEPATOTOXIC

CAUSES MI

Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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Side effects of PPAR-gamma agonists

takes 6-12 weeks to be effective

HEPATOTOXIC

CAUSES MI

Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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List the biguanides

metformin

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Mechanism of biguanides

blocks GNG

Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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Side effects of Biguanides

weight loss
improvement of lipid profile
LACTIC ACID ACIDOSIS
RENAL FAILURE WITH IODINATED CONTRAST

Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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List the alpha-glucosidase inhibitors

acarbose
miglitol

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Mechanism of alpha-glucosidase inhibitors

stops intestinal absorption of carbohydrates

Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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The only drug that can be used for insulin-dependent or insulin-independent diabetes

pralimitide: amylin analog

Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes, type 2 diabetes
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Lispro is a...

short-acting insulin analog

Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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Aspart is a...

short-acting insulin analog

Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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Glargine is a...

long-acting insulin analog

Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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Glulisine is a...

short-acting insulin analog

Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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Detemir is a...

intermediate-acting insulin analog

Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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Acetohexamide is a...

first generation sulfonylurea oral hypoglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Tolbutamide is a...

first generation sulfonylurea oral hypoglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Tolazamide is a...

first generation sulfonylurea oral hypoglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Acetohexamide is a...

first generation sulfonylurea oral hypoglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Chlorpropamide is a...

first generation sulfonylurea oral hypoglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Glyburide is a...

second generation sulfonylurea oral hypoglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Glipizide is a...

second generation sulfonylurea oral hypoglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Repaglinide is a...

meglitinide oral hypoglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Exenatide is a...

incretin mimetic oral hypoglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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Sitagliptin is a...

DPP4 inhibitor/gliptin oral hypoglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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40
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Vildagliptin is a...

DPP4 inhibitor/gliptin oral hypoglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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41
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Rosiglitazone is a...

TZD/PPAR-gamma agonist oral anti-hyperglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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42
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Pioglitazone is a...

TZD/PPAR-gamma agonist oral anti-hyperglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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43
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Metformin is a...

biguanide oral anti-hyperglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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44
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Acarbose is a...

alpha-glucosidase inhibitor oral anti-hyperlycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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45
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Miglitol is a...

alpha-glucosidase inhibitor oral anti-hyperglycemic

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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46
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Pramlinitide is a...

amylin analog injectable Type 1 and Type 2 diabetic drug

Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes, type 2 diabetes
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47
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List the short-acting Insulin Analogs

lispro
aspart
glulisine

Tags: diabetes, drugs, endo, pharmacology, Type I diabetes
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48
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List the long-acting Insulin Analogs

glargine

Tags: diabetes, drugs, endo, pharmacology, Type I diabetes
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List the intermediate-acting Insulin Analogs

detemir - binds to albumin

Tags: diabetes, drugs, endo, pharmacology, type 1 diabetes
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50
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List the Oral Hypoglycemics and their mechanisms

Sulfonylureas - inhibit ATP/K+ channels

Meglitinides - inhibit ATP/K+ channels

Incretin Mimetics (exenatide) - GLP1 agonists

Gliptins - inhibit DPP4 and block GLP1 and GIP metabolism

Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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51
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Tell me everything about first generation Sulfonylureas (names, mechanism, side effects)

tolbutamide, tolazamide, acetohexamide, chlorpropamide

inhibit ATP/K+ channels

SEVERE PROTRACTED HYPOGLYCEMIA THAT KILLS
WEIGHT GAIN

Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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List the second generation Sulfonylureas

glyburide, glipizide

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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53
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List the first generation Sulfonylureas

tolbutamide
tolazamide
acetohexamide
chlorpropamide

Tags: diabetes, drugs, endo, pharmacology, type 2 diabetes
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54
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Mechanism of first generation Sulfonylureas

inhibit ATP/K+ channels

Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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55
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Mechanism of second generation Sulfonylureas

inhibit ATP/K+ channels AND increase insulin receptors on tissues

Tags: diabetes, drug classes, endo, mechanisms, pharmacology, type 2 diabetes
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Side effects of sulfonylureas

First generation: SEVERE PROTRACTED HYPOGLYCEMIA THAT KILLS, weight gain

Second generation: weight gain only

Tags: diabetes, drug classes, endo, pharmacology, type 2 diabetes
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Flashcard set info:

Author: larsonsc

Main topic: Pharmacology

Topic: DM drugs

School / Univ.: MSUCOM

Published: 10.03.2010

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All cards (56)

classes (1)

diabetes (56)

drug classes (19)

drugs (36)

endo (56)

mechanisms (11)

pharmacology (56)

type 1 diabetes (8)

type 2 diabetes (47)

Type I diabetes (3)

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Diabetes (56 Cards)